Matt received his Ph.D. from the chemistry department at University of California at Berkeley, working with Kevan Shokat developing chemical methods to make synthetic chromatin substrates to study the biochemistry of epigenetics. He continued this work as a Helen Hay Whitney post doctoral fellow in Robert Kingston's laboratory at the Massachusetts General Hospital, where his interests expanded to include large non-coding RNAs and their impact on chromatin. In 2013 he began as an assistant professor at Yale University in the Department of Molecular Biophysics and Biochemistry, with his lab located in The Chemical Biology Institute on Yale's West Campus. His group focuses on developing new chemical and biochemical means of investigating RNA biology and especially non-coding RNAs that influence chromatin biology. He is a Searle Scholar and an NIH New Innovator.
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